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Buy viagra online In a second pharmacokinetic examine, single doses and a quantity of doses of dapoxetine were evaluated in a randomized, open-label, two-treatment, two-period, crossover research of forty two healthy male volunteers over 9 days [Modi et al. 2006]. Subjects acquired a single dose of dapoxetine 30 mg or 60 mg on day 1 (single-dose phase) and on days 4–9 (multiple-dose phase). Dapoxetine was rapidly absorbed, with mean maximal plasma concentrations of 297 and 498 ng/ml at 1.01 and 1.27 h after single doses of dapoxetine 30 and 60 mg, respectively . Elimination of dapoxetine was speedy and biphasic, with an preliminary half life of 1.31 and 1.42 h, and a terminal half life of 18.7 and 21.9 h following single doses of dapoxetine 30 and 60 mg, respectively. The pharmacokinetics of dapoxetine and its metabolites were not affected by repeated every day dosing and steady state plasma concentrations were reached within four days, with only modest accumulation of dapoxetine (approximately 1.5 fold) (Figure 2). generic viagra.
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